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KMID : 1143420200130392860
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Public Health Weekly Report
2020 Volume.13 No. 39 p.2860 ~ p.2870
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The prevalence of Pathogenic Escherichia coli isolated by the Enteric Pathogens Active Surveillance Network (Enter-Net), 2010-2019
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Yun Young-Sun
Kim Nan-Ok
Hong Sa-Hyun
Chun Jeong-Hoon
Hwang Kyu-Jam
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Abstract
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Pathogenic Escherichia coli (E. coli) causes diseases such as abdominal pain, enteritis, hemolytic uremic syndrome, sepsis, and meningitis in humans, and is managed as a legal infectious disease in Korea. The aim of this study was to provide information to health practitioners for the prevention and management of infectious diseases by providing ten-year (2010-2019) data on the prevalence and characteristics of pathogenic E. coli as collected by the Enteric Pathogens Active Surveillance Network (Enter-Net). Findings indicated that a total of 6,485 isolates were collected from domestic residents (5,785; 89.2%) and foreign travelers (700; 10.8%) in Korea between 2010 and 2019. Most of the pathogenic E. coli (5,785; 89.2%) were isolated from domestic residents. Enteropathogenic Escherichia coli (EPEC) (3,921; 60.5%) was the most prevalent pathovar followed by, in descending order, Enterotoxigenic Escherichia coli (ETEC) (2,025; 31.2%), Enterohemorrhagic Escherichia coli (EHEC) (438; 6.8%), and Enteroinvasive Escherichia coli (EIEC) (101; 1.6%). Among the ETEC cases, 556 (27.5%) strains were collected from foreign travelers; continuous monitoring through quarantine was required. The isolation rate, according to age group and season, was highest among children under nine years of age (37.0%) and was highest in the summer season (June to September). The major pathogenic genes of EHEC, EPEC, ETEC, and EIEC were stx1 (45.7%), eaeA (97.4%), st (53.4%), and the ipaH (100.0%), respectively. The majority of the EHEC strains (57.5%) harbored both stx and eaeA. The major serogroups of EHEC were divided with O157 (17.1%), O103 (12.8%), O26 (8.0%), O111 (5.0%), O91 (4.1%), O8 (3.0%), O108 (2.3%). The major serogroups isolated in Korea, the United States, Europe, Canada, and Japan were O157, O103, O26, O111, and O91, respectively. Serogroups specifically highly isolated in Korea were O108 and O8. The incidence of the most frequently isolated O157 gradually decreased from 42.4% in 2010, showing a lower isolation rate compared to other developed countries. However, this study recommended continuous monitoring of the changes in serogroups as the Korean diet becomes more westernized. This study concluded that it is necessary to provide useful scientific information for the prevention of infectious diseases by analyzing the prevalence and characteristics of pathogens for infectious diseases through the continuous development of the national surveillance system.
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KEYWORD
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Pathogenic E. coli, Enteric Pathogens Active Surveillance Network (Enter-Net), EHEC, EPEC, ETEC, EIEC
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